Pooled In-vitro CRISPR Knockout Library Essentiality Screens (PICKLES)


Welcome to PICKLES, the database of Pooled In vitro CRISPR Knockout Library Essentiality Screens, where end users can display and download raw or normalized essentiality profiles for more that 18,000 protein-coding genes across more than 50 cell lines. An additional data set with 15,000 genes targeted by pooled library shRNA in over 100 cell lines is also included. PICKLES allows expert and novice biologists the opportunity to see at a glance the relative fitness defect and tissue specificity of their genes of interest, generate and save figures locally, and download all raw data.